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  4. Surface Functionalized Substrates for Rapid Mass Spec Calibration

Surface Functionalized Substrates for Rapid Mass Spec Calibration

Fast calibration using novel substrates with differential wetting and surface energy traps

Mass spectronometer machine
Mass spectromoeter machine, for illustrative purposes only. Source: Adobe Stock, ©tilialucida.

Background

Mass spectrometry is a vital tool in analytical science, providing accurate and sensitive analysis of various compounds. Calibration is essential for quantitative analysis, requiring a relationship between ion signals and analyte concentration. Traditional calibration methods are time-consuming, cumbersome, and often require large sample quantities and highly trained professionals. These challenges highlight the need for more efficient and user-friendly calibration techniques.

Technology Overview

These substrates utilize differential wetting in conjunction with surface energy traps (SETs) to achieve rapid and efficient mass spectrometry calibration using minimal sample quantities (1 pL – 1 µL). Comprising oleophilic regions on an oleophobic surface, the substrates enable quick and accurate calibration using small amounts of liquid. These substrates are fabricated through laser micromachining, enabling the generation of calibration curves with up to 15 data points within 3 minutes.

The technology uses an automated xyz stage, such as that of a 3D printer, to move the mass spec from one SET to another, rapidly generating accurate calibration curves using a single substrate. Experiments using caffeine as the analyte have demonstrated a linear regression with an R² of 0.96, showcasing the potential for fast and cost-effective quantification of analytes on surfaces.

Benefits

  • Speed: Generates a 10-point calibration curve within 2.5 minutes, significantly reducing calibration time.
  • Efficiency: Uses minimal liquid sample quantities, beneficial for scarce or expensive samples.
  • User-Friendly: Reduces the need for highly trained professionals in sample preparation and introduction to the mass spectrometer.
  • Cost-Effective: Reduces overall calibration costs by minimizing liquid sample usage and time.
  • Scalability: Potential for miniaturization and integration with liquid chromatography for enhanced separation and detection.

Applications

  • Mass Spectrometry Manufacturers: Companies like Sciex and Waters can integrate this technology to enhance their product offerings.
  • Analytical Science Laboratories: Laboratories can benefit from faster and more efficient calibration processes.
  • Pharmaceutical Industry: Rapid and accurate quantification of drug compounds.
  • Environmental Monitoring: Quick analysis of trace contaminants in environmental samples.
  • Biotechnology: Calibration for protein and biomolecule analysis.

Opportunity

This innovation is ready for further development and commercialization. Mass spectrometer manufacturers, analytical labs, and companies in similar industries are likely to find this technology valuable. Interested parties are invited to explore collaboration and licensing opportunities to bring this technology to market.

Patents

IP Status

Patent application submiteed

Seeking

  • Development partner, 
  • Commercial partner, 
  • Licensing

Published

September 25, 2024